Chitosan/Au nanocomposites-based LSPR sensor for SARS-CoV-2  detection

M. H. C. Tlomatsane; L. Thwala; Z. K. S. Mcotshana; S. Ombinda-Lembouba; C. Williamson; P. Mthunzi-Kufa

doi:10.1117/12.3002495

12 March 2024 Chitosan/Au nanocomposites-based LSPR sensor for SARS-CoV-2 detection

M. H. C. Tlomatsane, L. Thwala, Z. K. S. Mcotshana, S. Ombinda-Lembouba, C. Williamson, P. Mthunzi-Kufa

Proceedings Volume 12840, Optical Interactions with Tissue and Cells XXXV; 128400L (2024) https://doi.org/10.1117/12.3002495
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Chitosan-based nanoparticles (NPs) are well-known for their safely, nontoxicity, biocompatibility, and biodegradability. Since highly infectious viral diseases such as Covid-19 spread quickly, it is important to be able to diagnose these diseases early to prevent the infection from spreading. In this study, we developed a novel highly sensitive chitosan/gold nanoparticles based LSPR sensor for SARS-CoV-2 virus detection. Localized surface plasmon resonance (LSPR) is an optical phenomenon caused by collective electron charge oscillations in metallic nanoparticles excited by light source. The nanocomposites of gold nanoparticles (AuNPs) with chitosan were synthesized by the reduction technique. Chitosan/Au nanocomposites were synthesized by reducing gold salt using chitosan. Chitosan acted as a reducing/stabilizing agent to produce composites. SARS-CoV- 2 antibodies were conjugated with Chitosan/Au nanocomposites for detection of the target antigen using LSPR.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

M. H. C. Tlomatsane, L. Thwala, Z. K. S. Mcotshana, S. Ombinda-Lembouba, C. Williamson, and P. Mthunzi-Kufa "Chitosan/Au nanocomposites-based LSPR sensor for SARS-CoV-2 detection", Proc. SPIE 12840, Optical Interactions with Tissue and Cells XXXV, 128400L (12 March 2024); https://doi.org/10.1117/12.3002495

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