LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment

Mithun Kuniyil Ajith Singh; Naoto Sato; Fumiyuki Ichihashi; Yoshiyuki Sankai

doi:10.1117/12.3002637

12 March 2024 LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment

Mithun Kuniyil Ajith Singh, Naoto Sato, Fumiyuki Ichihashi, Yoshiyuki Sankai

Author Affiliations +

Proceedings Volume 12842, Photons Plus Ultrasound: Imaging and Sensing 2024; 128420X (2024) https://doi.org/10.1117/12.3002637
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Accurate assessment of microvasculature and oxygen saturation is vital for diagnosing and monitoring diseases, including cancer. However, the current clinical need for point-of-care (POC), non-invasive, and cost-effective imaging approaches remains unmet. Photoacoustic imaging, offering natural blood contrast, holds potential for high-resolution vascular imaging. Yet, the requirement for bulky and expensive lasers impedes its clinical translation, particularly in resource-limited settings. Recent advances in using high-power LED arrays for photoacoustic imaging are promising due to their portability, affordability, and ease-of-use in clinical settings. In this work, we demonstrate the potential of LED-based photoacoustic imaging for microvascular health assessment through in vivo human volunteer imaging. Real-time 2D and 3D experiments evaluated LED-based photoacoustic imaging in assessing vascular density, arterial distensibility, and blood oxygen saturation with high resolution. Our results confirm that LED-based photoacoustic imaging may serve as an invaluable POC tool for microvascular health assessment in resource-limited settings. The affordability and simplicity of LED arrays present a compelling alternative to laser-based approaches, expanding accessibility in clinical practice. This advancement has the potential to enhance early disease detection and treatment monitoring, particularly in areas with limited access to sophisticated imaging technologies.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mithun Kuniyil Ajith Singh, Naoto Sato, Fumiyuki Ichihashi, and Yoshiyuki Sankai "LED-based photoacoustic imaging: a point-of-care solution for microvascular health assessment", Proc. SPIE 12842, Photons Plus Ultrasound: Imaging and Sensing 2024, 128420X (12 March 2024); https://doi.org/10.1117/12.3002637

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