THz metamaterial biodetection platform for label-free, sensitive and selective DNA-, protein- or supermolecular-based biomarker analysis

Merle Richter; Yannik Loth; Nicole Rachinger; Anna K. Wigger; Anja K. Bosserhoff; Peter Haring Bolívar

doi:10.1117/12.3016084

18 June 2024 THz metamaterial biodetection platform for label-free, sensitive and selective DNA-, protein- or supermolecular-based biomarker analysis

Merle Richter, Yannik Loth, Nicole Rachinger, Anna K. Wigger, Anja K. Bosserhoff, Peter Haring Bolívar

Author Affiliations +

Proceedings Volume 12994, Terahertz Photonics III; 1299409 (2024) https://doi.org/10.1117/12.3016084
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

This work is dedicated to present a versatile, metamaterial-based sensing platform for biomarker detection in the THz frequency regime. The sensor can be classified as frequency selective surface and exhibits a characteristic dual resonance feature in the transmission frequency response which has been proven to perform well in biosensing applications. The platform is able to selectively detect proteins such as transcription factor EGR2 (early growth response protein 2) from a complex sample matrix with more than 7 · 10³ other protein species, to sensitively detect reverse-transcribed MIA (melanoma inhibitory activity) DNA from a complex sample matrix and to respond to extracellular vesicular structures as well.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Merle Richter, Yannik Loth, Nicole Rachinger, Anna K. Wigger, Anja K. Bosserhoff, and Peter Haring Bolívar "THz metamaterial biodetection platform for label-free, sensitive and selective DNA-, protein- or supermolecular-based biomarker analysis", Proc. SPIE 12994, Terahertz Photonics III, 1299409 (18 June 2024); https://doi.org/10.1117/12.3016084

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