Ultra-trace detection of biomarker employing Au gratings as highly sensitive SERS-active substrate

Sibashish Chakraborty; Richa Goel; Vimarsh Awasthi; Gaurav Jayaswal; Satish K. Dubey

doi:10.1117/12.3022333

20 June 2024 Ultra-trace detection of biomarker employing Au gratings as highly sensitive SERS-active substrate

Sibashish Chakraborty, Richa Goel, Vimarsh Awasthi, Gaurav Jayaswal, Satish K. Dubey

Proceedings Volume 12999, Optical Sensing and Detection VIII; 129991M (2024) https://doi.org/10.1117/12.3022333
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Surface Enhanced Raman Spectroscopy, also known as SERS, is a technology that has developed into an effective, rapid, accurate, and sensitive method for the detection and analysis of any analyte at the ultra-trace level. This is accomplished by the enhancement of the Raman signal. The SERS technique allows for the identification of very low quantities of Raman-active analytes by coupling electromagnetic radiation at optical frequency. There is a substantial amount of interest in the study of the design and development of SERS-active substrates due to the fact that these substrates are of crucial importance in the process of Raman signal amplification. In this study, we have demonstrated EBL fabricated, Au-gratings nanopattern as SERS-active substrate for detection of Rhodamine 6G and a bio-molecule urea up to 10^-9 M concentration. NIR laser source (λ=785nm) was used to collect Raman spectra using Raman set up (Renishaw). As part of normal bodily functions, the liver releases urea into the blood, which is transported to the kidneys and expelled as urine, serving as a biomarker for kidney disease. Gas chromatography and calorimetry can detect low quantities of urea, but they are time-consuming and costly. As a low-cross-section molecule, urea can be adsorbed on noble-metal NPs and detected at trace amounts using SERS. There are a number of other possible applications for the SERS-active substrate that has been presented. These applications include in-situ detection of food and water adulterants, narco-analysis etc.

Conference Presentation

Citation Download Citation

Sibashish Chakraborty, Richa Goel, Vimarsh Awasthi, Gaurav Jayaswal, and Satish K. Dubey "Ultra-trace detection of biomarker employing Au gratings as highly sensitive SERS-active substrate", Proc. SPIE 12999, Optical Sensing and Detection VIII, 129991M (20 June 2024); https://doi.org/10.1117/12.3022333

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