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2-propanol is a secondary alcohol that exhibits different associations with a variety of diseases across diverse organic samples. Notably, elevated levels of 2-propanol in urine samples have been linked to type II diabetes, whereas a decrease in its concentration is observed in cases of malignant biliary strictures. In feces, an increase in 2-propanol is associated with colorectal cancer. Furthermore, disturbances in 2-propanol levels in breath have been correlated with various types of cancers. These findings underscore the potential utility of 2-propanol as a biomarker for disease detection across multiple biological matrices. In this study, we propose a sensor that combines a multimode interference structure with a molecularly imprinted polymer (MIP) functionalization. The multimode sensor is created by fusion splicing a coreless fiber section to a single-mode fiber (SMF). For coating the coreless fiber (CSF), the dip coating technique was utilized, employing a MIP with 2-propanol as the template, and separately, the corresponding non-imprinted polymer (NIP). Our findings reveal that the MIP demonstrates specificity for 2-propanol in the gas phase, showing a sensitivity of 13 pm/wt.% 2-propanol. In contrast, the corresponding NIP lacks sensitivity to 2-propanol. This outcome emphasizes the potential of our proposed sensor design for the selective detection of 2-propanol, thereby highlighting its applicability in gas phase analyses. |
