Several low-cost, highly sensitive, simple-to-realize and to-use Point-Of-Care-Tests (POCT) have been presented exploiting plasmonic optical fiber sensors. In particular, highly sensitive biosensor configurations are developed by using innovative platforms that efficiently excite the plasmonic phenomena (surface plasmon resonance or Localized surface plasmon resonance) in gold films, continuous or nanostructured. This work proposes an overview of how a designer could tailor the sensor’s components, i.e. the plasmonic transducer and the receptor, to modify the response of the bio/chemical sensor system in terms of substance to be detected and detection range, as well. The proper combination of these two components (transducer and receptor) would produce the desired optimal performance for POCT. For instance, the detection range can be changed from femtomolar to micromolar ranges.
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