An imaging device with 405 nm LED illumination at power density 7 mW/cm2 was used for cutaneous autofluorescence excitation. Autofluorescence photobleaching was detected by imaging under continuous irradiation for 20 seconds. It was found that on average basal cell carcinoma in patients with basal cell nevus syndrome has a lower autofluorescence intensity at the first second of excitation, as well as smaller decrease in intensity after 20 seconds of irradiation compared to sporadic basal cell carcinoma. This may show that basal cell carcinoma in patients with basal cell nevus syndrome have a different composition of endogenous fluorophores than in sporadic cases which could be investigated in further research. |
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