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Accurate measurement of small RIU, surface refractive index (RI) changes is crucial in biosensing. This study introduces a novel approach to correlate intricate spectral features with RI variations in Surface Plasmon Resonance (SPR) sensing using optical fiber gratings. Using a regression model with gold-coated tilted fiber Bragg grating (Au-TFBG) sensors, we achieve enhanced signal stability and precision across diverse experimental setups. This eliminates the need for sensor calibration, streamlining biosensing protocols. Our findings represent a significant advancement in real-time RI monitoring, offering promising applications in biosensing.
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Hadrien Fasseaux, Médéric Loyez, Evelyne Meurisse, Pierre Denis, Christophe Caucheteur, "Revealing surface refractive index dynamics in comb-like plasmonic optical fiber biosensors," Proc. SPIE 13011, Data Science for Photonics and Biophotonics, 1301103 (18 June 2024); https://doi.org/10.1117/12.3017156