Potential molecular mechanisms of postoperative restenosis in lower extremity Atherosclerotic occlusive disease

Zilin lu; Xianfei Liu; Peiqi Li

doi:10.1117/12.3036630

13 July 2024 Potential molecular mechanisms of postoperative restenosis in lower extremity Atherosclerotic occlusive disease

Zilin lu, Xianfei Liu, Peiqi Li

Author Affiliations +

Proceedings Volume 13208, Third International Conference on Biomedical and Intelligent Systems (IC-BIS 2024); 132080G (2024) https://doi.org/10.1117/12.3036630
Event: 3rd International Conference on Biomedical and Intelligent Systems (IC-BIS 2024), 2024, Nanchang, China

Abstract

Arteriosclerosis obliterans (ASO) of the lower limbs is a common peripheral arterial disease encountered in clinical practice, which has caused a large numbers of amputation in middle-aged and elderly individuals. The treatments of ASO are frequently associated with restenosis and adverse events after surgical recanalization. In this study, bioinformatics were used to analyze 75 ASO patients from two GEO databases. Multi-algorithm joint filtering of key mutation sites, biological function annotation and intervened disease model verification were performed to screen out the core genes that may be related to pathological vascular remodeling. Genes with higher expression in occlusive lower extremity artery than the normal, which may undergo pathogenic mutations, were conjectured to result a more profound adverse influence on vascular structure. Our study reveales that matrix metalloproteinase 9 (MMP9) has recurring harmful up-regulated in occlusive artery and inhibition of MMP9-related proteins decreases the degree of foam in smooth muscle cells in vitro and in vivo. Based on this, we conclude that MMP9 may play a key role in the onset and progression of ASO in lower extremity artery by controlling smooth muscle cell phenotypic shift.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Zilin lu, Xianfei Liu, and Peiqi Li "Potential molecular mechanisms of postoperative restenosis in lower extremity Atherosclerotic occlusive disease", Proc. SPIE 13208, Third International Conference on Biomedical and Intelligent Systems (IC-BIS 2024), 132080G (13 July 2024); https://doi.org/10.1117/12.3036630

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