Raman and multichannel Raman spectroscopy of biological systems

Alessandro Bertoluzza; R. Caramazza; C. Fagnano

doi:10.1117/12.57278

1 May 1991 Raman and multichannel Raman spectroscopy of biological systems

Alessandro Bertoluzza, R. Caramazza, C. Fagnano

Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57278
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

Raman and multichannel Raman spectroscopy are molecular techniques able to monitor the bulk and surface structure of a biomaterial, in a non destructive and non invasive way, giving therefore useful information on physical and chemical aspects of biocompatibility. The same techniques can also be adequately used for the characterization of the biomaterial-host tissue interface, hence providing structural information on the biochemical aspect of biocompatibility. Moreover, multichannel Raman spectroscopy can also determine "in vivo" and "in situ" the bulk and surface structure of a biomaterial and the molecular interactions between biomaterials and tissues. Useful information at a molecular level on the biomaterial-tissue system can so be deduced. In particular, the application of traditional Paman spectroscopy to bioactive glasses (glasses derived from Hench's bioglass and meta and oligophosphates of calcium by themselves and with the addition of sodium and aluminium) useful in orthopedics and the application to hydrophobic (PMMA) and hydrophilic (PHEMA and PVP) organic polymers useful in ophthalmology are shown. Instead the applications of multichannel Paman spectroscopy are elucidated in the case of intraocular lenses (lOLs) based on PMMA and contact lenses (CLs) based on hydrophi I ic polymers.

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Alessandro Bertoluzza, R. Caramazza, and C. Fagnano "Raman and multichannel Raman spectroscopy of biological systems", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57278

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KEYWORDS

Raman spectroscopy

Glasses

Tissues

Natural surfaces

Polymers

Polymethylmethacrylate

Calcium

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