Histopathologic assessment of water-dominated photothermal effects produced with laser irradiation

Sharon L. Thomsen M.D.; Wai-Fung Cheong; John Anthony Pearce

doi:10.1117/12.43935

1 June 1991 Histopathologic assessment of water-dominated photothermal effects produced with laser irradiation

Sharon L. Thomsen M.D., Wai-Fung Cheong, John Anthony Pearce

Author Affiliations +

Proceedings Volume 1422, Lasers in Dermatology and Tissue Welding; (1991) https://doi.org/10.1117/12.43935
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

As the temperature of heated tissues approach 100 degree(s)C the pathological results of laser irradiation become dominated by the effects of phase changes in tissue water. The tissue effects include tissue desication and, as the temperature passes 100 degree(s)C, steam vacuole formation with expansion and rupture of the vacuoles producing tissue defects without loss of dry tissue mass, the so-called 'popcorn effect'. More rapid rates of steam formation result in explosive rupture of the vacuoles with expulsion of tissue fragments producing ablation, a loss of dry tissue mass. Water-dominated photothermal tissue effects are dependent on (1) diffusion of water vapor in tissues at temperatures below 100 degree(s)C, (2) rate of steam formation over 100 degree(s)C, (3) the mechanical properties of the heated tissues over time and (4) the anatomy of the 'native' target tissue.

Citation Download Citation

Sharon L. Thomsen M.D., Wai-Fung Cheong, and John Anthony Pearce "Histopathologic assessment of water-dominated photothermal effects produced with laser irradiation", Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991); https://doi.org/10.1117/12.43935

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