Heat-free photochemical tissue welding with 1,8-naphthalimide dyes using visible (420 nm) light

Millard M. Judy; James Lester Matthews; Richard L. Boriak; A. Burlacu; Dorothy E. Lewis; Ronald E. Utecht

doi:10.1117/12.147028

1 July 1993 Heat-free photochemical tissue welding with 1,8-naphthalimide dyes using visible (420 nm) light

Millard M. Judy, James Lester Matthews, Richard L. Boriak, A. Burlacu, Dorothy E. Lewis, Ronald E. Utecht

Proceedings Volume 1876, Lasers in Otolaryngology, Dermatology, and Tissue Welding; (1993) https://doi.org/10.1117/12.147028
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

We have newly designed and synthesized a class of photochemical 1,8-naphthalimide dyes. Photochemical investigation strongly suggests that these dyes function as photoalkylation agents following activation to an intermediate state by visible light (circa 420 nm) excitation. The activated species reacts readily with nucleophilic amino acid residues; e.g., tryptophan, tyrosine, cysteine, and methionine. One such dye, 1,14-bis(N-hexyl-3'-bromo- 1,8'-naphthalimid-4'-yl)-1,4,11,14-tetraazatetradecane-5,10-dione, incorporating two reactive 1,8-naphthalimide groups at each end of an intervening structural bridge has been used to achieve photochemical or photoactivated bonding (welding) of collagenous dura mater sheets to each other. Weld shear strengths of up to 425 gm/cm² (1.14 X 10⁴ Nt/m²) have been obtained.

Citation Download Citation

Millard M. Judy, James Lester Matthews, Richard L. Boriak, A. Burlacu, Dorothy E. Lewis, and Ronald E. Utecht "Heat-free photochemical tissue welding with 1,8-naphthalimide dyes using visible (420 nm) light", Proc. SPIE 1876, Lasers in Otolaryngology, Dermatology, and Tissue Welding, (1 July 1993); https://doi.org/10.1117/12.147028

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