Interstitial laser photocoagulation therapy for liver tumors: clinical results

Zahir Amin; J. J. Donald; A. Masters; R. Kant; William R. Lees M.D.; Stephen G. Bown

doi:10.1117/12.147660

7 July 1993 Interstitial laser photocoagulation therapy for liver tumors: clinical results

Zahir Amin, J. J. Donald, A. Masters, R. Kant, William R. Lees M.D., Stephen G. Bown

Proceedings Volume 1882, Laser-Tissue Interaction IV; (1993) https://doi.org/10.1117/12.147660
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Interstitial laser photocoagulation is a new technique of tumor ablation using low power (2 W) laser light over a long time (500 s) via thin (0.2 mm) optical fibers. We have treated 26 patients with 70 liver metastases measuring 1 to 15 cm (median 2.5 cm). There were 1 to 8 treatment sessions per patient (median 3). Each tumor was treated via 1 to 4 optical fibers. The median energy used was 16000 J (range 3000 to 34000 J). Treatment effects were monitored in real-time with ultrasound, and the extent of tumor necrosis evaluated 1 to 3 days later using dynamic enhanced CT which showed laser-induced necrosis as well-defined new areas of non-enhancement. Greater than 50% necrosis of tumor volume was achieved in 86% (60 out of 70) of the tumors treated, and 100% necrosis in 53% (37 out of 70). Metastases under 4 cm were treated more effectively and required fewer treatment sessions than those over 4 cm. In eleven patients there was evidence of disease progression (follow-up 14 months or longer) and in 15 patients there has been overall tumor reduction (follow-up less than 1 year, median 4 months). Conclusion: With further development, ILP may offer a practical and minimally invasive alternative to major surgery for eradicating small, deep seated tumors, and debulking larger ones.

Citation Download Citation

Zahir Amin, J. J. Donald, A. Masters, R. Kant, William R. Lees M.D., and Stephen G. Bown "Interstitial laser photocoagulation therapy for liver tumors: clinical results", Proc. SPIE 1882, Laser-Tissue Interaction IV, (7 July 1993); https://doi.org/10.1117/12.147660

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