Phthalocyanines as second generation photosensitizers for the photodynamic therapy of cancer: fluorescence and absorption spectroscopy

L. V. Zhorina; Elena B. Chernyaeva; A. V. Agronskaya; Maria G. Galpern

doi:10.1117/12.178996

28 June 1994 Phthalocyanines as second generation photosensitizers for the photodynamic therapy of cancer: fluorescence and absorption spectroscopy

L. V. Zhorina, Elena B. Chernyaeva, A. V. Agronskaya, Maria G. Galpern

Author Affiliations +

Proceedings Volume 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy; (1994) https://doi.org/10.1117/12.178996
Event: Volga Laser Tour '93, 1993, Moscow, Russian Federation

Abstract

We studied the pH-dependence of the fluorescence and absorption spectra of concentrated solutions of tetrasulphonated aluminum phthalocyanine (AlPcS₄)--the potent photosensitizer for the photodynamic therapy of cancer. The possible use of AlPcS₄ as the pH-sensitive fluorescent probe for local pH measurements is discussed. By means of numerical Alentsev's procedure the individual spectral components of the fluorescence spectrum main band were resolved.

Citation Download Citation

L. V. Zhorina, Elena B. Chernyaeva, A. V. Agronskaya, and Maria G. Galpern "Phthalocyanines as second generation photosensitizers for the photodynamic therapy of cancer: fluorescence and absorption spectroscopy", Proc. SPIE 2100, Cell and Biotissue Optics: Applications in Laser Diagnostics and Therapy, (28 June 1994); https://doi.org/10.1117/12.178996

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