Measurements and simulations of dynamic light scattering in an upscaled tissue blood flow model

Frits F. M. de Mul; Jan Greve; Marco H. Koelink; Reindert Graaff; Jan G. Aarnoudse

doi:10.1117/12.200828

31 January 1995 Measurements and simulations of dynamic light scattering in an upscaled tissue blood flow model

Frits F. M. de Mul, Jan Greve, Marco H. Koelink, Reindert Graaff, Jan G. Aarnoudse

Proceedings Volume 2326, Photon Transport in Highly Scattering Tissue; (1995) https://doi.org/10.1117/12.200828
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

In order to study the behavior of laser-Doppler based tissue blood perfusion meters an experimental flow model has been developed consisting of a set of layers with dispersed scatterers and/or absorbing material which are moveable with respect to each other and to the laser-Doppler probe. As the material for the layers gelatin was used, and for the scatterers polystyrene spheres were chosen. Light (from a diode laser) scattering in the sample was measured in reflection using a photodiode array. The intensity and the Doppler spectrum were recorded as a function of the source-detector distance and the angle of laser light incidence. For comparison a number of Monte Carlo simulations of the dynamic light scattering in the sample were performed. The simulations included data regarding the Doppler spectrum, the number of scatter events, paths lengths, positions and angles of emergence and penetration depths. It is seen that in the heterodyne detection case good agreement between measurements and simulations is obtained, while in the homodyne the simulations have to be downscaled in frequency (factor 3). This may be caused by coherence effects due to the finite aperture of the detector. In the simulations the averaged Doppler frequency and averaged absolute Doppler frequency turn out to be quadratic and linear dependent on the numerical aperture. This effect was verified with an independent calculation.

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Frits F. M. de Mul, Jan Greve, Marco H. Koelink, Reindert Graaff, and Jan G. Aarnoudse "Measurements and simulations of dynamic light scattering in an upscaled tissue blood flow model", Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995); https://doi.org/10.1117/12.200828

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KEYWORDS

Doppler effect

Scattering

Photons

Monte Carlo methods

Homodyne detection

Sensors

Heterodyning

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