Photodynamic therapy of gastric cancer

Sergey S. Kharnas; N. M. Kuzin; Victor Ya. Zavodnov; Olga A. Sclyanskaya; Kirill G. Linkov; Victor B. Loschenov; Gennadii A. Meerovich; Nadezgda L. Torshina; Alexander A. Stratonnikov; Rudolf W. Steiner

doi:10.1117/12.230992

31 January 1996 Photodynamic therapy of gastric cancer

Sergey S. Kharnas, N. M. Kuzin, Victor Ya. Zavodnov, Olga A. Sclyanskaya, Kirill G. Linkov, Victor B. Loschenov, Gennadii A. Meerovich, Nadezgda L. Torshina, Alexander A. Stratonnikov, Rudolf W. Steiner

Author Affiliations +

Proceedings Volume 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities; (1996) https://doi.org/10.1117/12.230992
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Photodynamic therapy (PDT) with the use of laser endoscopic spectrum analyzer (LESA-5), the spectral-analyzing video-imaging system, Kr laser and various types of catheters for different tumor localizations, and Phthalocyanine aluminum photosensitizers in patients with gastric cancer was discussed. PDT was carried out in fifteen patients with gastric cancer. There were the following indications for PDT: early gastric cancer (3 patients), malignant stenosis of the cardia or pyloric portion of the stomach (4 patients), cancer of gastric stump with stenosis of gastrojejunal anastomosis (1 patient), preoperative treatment of patients with large but probably resectable gastric tumor size (7 patients). Usually we used 3 - 4 seances of laser treatment 10 - 30 minutes long. Concentration of photosensitizer in normal and malignant tissue was controlled by LESA-5. Treatment was monitored by spectral-analyzing video- imaging system in fluorescent light. The results show high efficiency of PDT especially in patients with early gastric cancer (necrosis of all tumor mass, i.e. complete regression of tumor). For all other patients we obtained partial regression of gastric cancer.

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Sergey S. Kharnas, N. M. Kuzin, Victor Ya. Zavodnov, Olga A. Sclyanskaya, Kirill G. Linkov, Victor B. Loschenov, Gennadii A. Meerovich, Nadezgda L. Torshina, Alexander A. Stratonnikov, and Rudolf W. Steiner "Photodynamic therapy of gastric cancer", Proc. SPIE 2625, Photochemotherapy: Photodynamic Therapy and Other Modalities, (31 January 1996); https://doi.org/10.1117/12.230992

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