Photodynamic effect occurance in photosensitizer mixtures with albumin or blood serum, or hemoglobin and blood

Nadezgda L. Torshina; Anna M. Posypanova; Anna I. Volkova

doi:10.1117/12.239538

10 May 1996 Photodynamic effect occurance in photosensitizer mixtures with albumin or blood serum, or hemoglobin and blood

Nadezgda L. Torshina, Anna M. Posypanova, Anna I. Volkova

Author Affiliations +

Proceedings Volume 2678, Optical Diagnostics of Living Cells and Biofluids; (1996) https://doi.org/10.1117/12.239538
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Under laser irradiation of different photosensitizers (PS) mixtures with pure albumin or without hemolysis blood serum the photodynamic effect (PE) is scarcely to be manifested. The coupling of PS with albumins prevents the interactions of dissolved oxygen molecules with PS molecules and formation of active oxygen forms. In order to promote the PE it is necessary to add the solution of hemoglobin. The PE is readily recognized in mixtures of PS with the blood. Such mixing leads to the erythrocytes' destruction and yields uncombined hemoglobin in blood plasma. The irradiation of hemoglobin mixtures with PS leads to the destruction of hemoglobin. In this case the direct combination of oxygen molecules with hemoglobin is important for PE performance (the deoxy hemoglobin can not promote PE otherwise).

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Nadezgda L. Torshina, Anna M. Posypanova, and Anna I. Volkova "Photodynamic effect occurance in photosensitizer mixtures with albumin or blood serum, or hemoglobin and blood", Proc. SPIE 2678, Optical Diagnostics of Living Cells and Biofluids, (10 May 1996); https://doi.org/10.1117/12.239538

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