How many molecules of a photosensitizer are necessary to photosensitize a tumor cell?

Joerg G. Moser; Franz-Peter Montforts; Dirk Kusch; Anja Vervoorts; Dieter Kirsch; Michael Berghahn; Nermin Akguen; Angelika C. Rueck; Sonja Andrees; Birgit Wagner

doi:10.1117/12.260749

4 December 1996 How many molecules of a photosensitizer are necessary to photosensitize a tumor cell?

Joerg G. Moser, Franz-Peter Montforts, Dirk Kusch, Anja Vervoorts, Dieter Kirsch, Michael Berghahn, Nermin Akguen, Angelika C. Rueck, Sonja Andrees, Birgit Wagner

Author Affiliations +

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260749
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

Diglycosylated porphyrinoids were shown to stack at the outer cell membrane of tumor cells in vitro. Similar phototoxicities are acquired as with the non-glycosylated drugs at amounts of only 1% of that normally taken up of the non-glycosylated drugs. This means that a strict positioning of sensitizers at sensitive compartments may reduce the amount of sensitizer necessary to sensitize a tumor cell to about 10⁶ molecules per cell. Similar numbers were seen only in erythrocytes and with immunoconjugates in ovarian cancer. This low amount facilitates photosensitizer transport against intratumoral pressure gradients.

Citation Download Citation

Joerg G. Moser, Franz-Peter Montforts, Dirk Kusch, Anja Vervoorts, Dieter Kirsch, Michael Berghahn, Nermin Akguen, Angelika C. Rueck, Sonja Andrees, and Birgit Wagner "How many molecules of a photosensitizer are necessary to photosensitize a tumor cell?", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260749

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