Measurement of the triplet-state yield of photosensitizers in scattering media

Brian W. Pogue; Lothar D. Lilge; Kai Zhang; Brian C. Wilson; Robert W. Redmond; Tayyaba Hasan

doi:10.1117/12.273502

8 May 1997 Measurement of the triplet-state yield of photosensitizers in scattering media

Brian W. Pogue, Lothar D. Lilge, Kai Zhang, Brian C. Wilson, Robert W. Redmond, Tayyaba Hasan

Proceedings Volume 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI; (1997) https://doi.org/10.1117/12.273502
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

A methodology is presented which enables quantification of the fraction of photosensitizer which is photo-converted to the triplet state within homogeneously scattering media. The method relies on a correlation of absorbance with diffuse reflectance changes measured in samples of photosensitizer in scattering medium and can estimate the fraction of photosensitizer molecules present in the active monomeric form. The validity of this approach is demonstrated for the sensitizer tin etioporphyrin in a model system of lipid in water emulsion and is expected to be applicable to biological systems such as cell suspensions and tissue.

Citation Download Citation

Brian W. Pogue, Lothar D. Lilge, Kai Zhang, Brian C. Wilson, Robert W. Redmond, and Tayyaba Hasan "Measurement of the triplet-state yield of photosensitizers in scattering media", Proc. SPIE 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI, (8 May 1997); https://doi.org/10.1117/12.273502

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