Variation of retinal ED50 with exposure duration for near-IR sources

David J. Lund; Daniel R. Fuller; Stephen W. Hoxie; P.R. Edsall

doi:10.1117/12.275254

2 May 1997 Variation of retinal ED₅₀ with exposure duration for near-IR sources

David J. Lund, Daniel R. Fuller, Stephen W. Hoxie, P.R. Edsall

Proceedings Volume 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment; (1997) https://doi.org/10.1117/12.275254
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

A body of data relates the ED₅₀ for laser-induced retinal damage to exposure duration for visible-wavelength laser exposure and for 1064 nm laser exposure. The database, extending from sub-nanosecond exposures to kilosecond exposures, can for the most part, be fit to models based on thermal interactions, thermal-mechanical mechanisms, and photochemical processes. Exceptions to this fit occur between 1 and 100 microseconds where the damage mechanism transitions from exclusively thermal to thermal-mechanical. Disagreement exists as to whether this anomalous dip of ED₅₀ is real or is an artifact of the data. We determined the laser-induced retinal ED₅₀ in Rhesus monkey eyes for several exposure durations from 12 nanoseconds to 1000 milliseconds at 755 nm using a dye laser, an alexandrite laser, and a Ti:Sapphire laser. These data do not show a dip in ED₅₀ in the microsecond time period.

Citation Download Citation

David J. Lund, Daniel R. Fuller, Stephen W. Hoxie, and P.R. Edsall "Variation of retinal ED₅₀ with exposure duration for near-IR sources", Proc. SPIE 2974, Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment, (2 May 1997); https://doi.org/10.1117/12.275254

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