Near-IR luminescent rare-earth ion complexes for sensitive diagnostics

Johannes W. Hofstraat; Martinus H.V. Werts; Jan W. Verhoeven

doi:10.1117/12.308042

1 May 1998 Near-IR luminescent rare-earth ion complexes for sensitive diagnostics

Johannes W. Hofstraat, Martinus H.V. Werts, Jan W. Verhoeven

Proceedings Volume 3253, Biomedical Sensing and Imaging Technologies; (1998) https://doi.org/10.1117/12.308042
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Rare-earth ions, with relatively long luminescence lifetimes, have significant advantages for diagnostic application. In diagnostics the long luminescence lifetimes allow for extremely sensitive time-gated detection, where the difference in temporal behavior of scatter and background fluorescence and the long-lived rare earth luminescence is utilized. Unfortunately the absorption cross-section of rare earth ion transitions is extremely low. However, via sensitized excitation by means of a suitable organic molecule efficient excitation is obtained. It is shown that excitation in the visible part of the spectrum can be used to excite rare-earth ions which luminescent in the near-IR, such as ytterbium, neodymium and erbium, via a fluorescein-derivative as sensitizer. The advantages of this approach are manifold. Low cost light source are available for the visible part of the spectrum and interference's from the matrix are minimal. Detection in the near-IR is almost interference-free.

Citation Download Citation

Johannes W. Hofstraat, Martinus H.V. Werts, and Jan W. Verhoeven "Near-IR luminescent rare-earth ion complexes for sensitive diagnostics", Proc. SPIE 3253, Biomedical Sensing and Imaging Technologies, (1 May 1998); https://doi.org/10.1117/12.308042

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