Novel low-cost fiber optic colorimetric instrument to rapidly screen premalignant esophageal tissue

Anupam K. Dattamajumdar; John A. Myers; Andrew H. Proctor; Douglas S. Levine; Patricia L. Blount; Brian J. Reid; Roy W. Martin

doi:10.1117/12.308050

1 May 1998 Novel low-cost fiber optic colorimetric instrument to rapidly screen premalignant esophageal tissue

Anupam K. Dattamajumdar, John A. Myers, Andrew H. Proctor, Douglas S. Levine, Patricia L. Blount, Brian J. Reid, Roy W. Martin

Author Affiliations +

Proceedings Volume 3253, Biomedical Sensing and Imaging Technologies; (1998) https://doi.org/10.1117/12.308050
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

A cost-efficient screening device is needed to detect patients who have Barrett's esophagus, a precursor to esophageal adenocarcinoma -- the most rapidly increasing cancer in the US. We have developed a prototype instrument based on colorimetric assessment of esophageal lumen. The system consists of a small diameter fiber-optic probe, interfacing electronics, a probe-head position sensor and a computer for display and analysis. The probe has a central plastic optical fiber through which white light is incident on the collapsed esophageal lumen via c conical mirror in the probe-head. A parabolic mirror in the probe-head focuses the reflected light is applied to a linear 520 X 3 RGB photo-diode array to generate proportional electrical signals. A position sensor tracks probe-head location as it is retracted, allowing generation of a 2D colormap of esophageal lumen. A color change from white to red indicates Barrett's esophagus. The system performed accurately in tests using models of esophageal lumen which simulate patterns observed in Barrett's esophagus.

Citation Download Citation

Anupam K. Dattamajumdar, John A. Myers, Andrew H. Proctor, Douglas S. Levine, Patricia L. Blount, Brian J. Reid, and Roy W. Martin "Novel low-cost fiber optic colorimetric instrument to rapidly screen premalignant esophageal tissue", Proc. SPIE 3253, Biomedical Sensing and Imaging Technologies, (1 May 1998); https://doi.org/10.1117/12.308050

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