Monte-Carlo simulations of arterial imaging with optical coherence tomography

Peter A. Amendt; Kent G. Estabrook; Matthew J. Everett; Richard A. London; Duncan J. Maitland; George B. Zimmerman; Bill W. Colston Jr.; Luiz Barroca Da Silva; Ujwal S. Sathyam

doi:10.1117/12.384157

28 April 2000 Monte-Carlo simulations of arterial imaging with optical coherence tomography

Peter A. Amendt, Kent G. Estabrook, Matthew J. Everett, Richard A. London, Duncan J. Maitland, George B. Zimmerman, Bill W. Colston Jr., Luiz Barroca Da Silva, Ujwal S. Sathyam

Author Affiliations +

Proceedings Volume 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV; (2000) https://doi.org/10.1117/12.384157
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The laser-tissue interaction code LATIS is used to analyze photon scattering histories representative of optical coherence tomography (OCT) experiments performed at Lawrence Livermore National Laboratory. Monte Carlo photonics with Henyey-Greenstein anisotropic scattering is implemented and used to simulate signal discrimination of intravascular structure. An analytic model is developed and used to obtain a scaling law for optimization of the OCT signal and to validate Monte Carlo photonics. The appropriateness of the Henyey-Greenstein phase function is studied by direct comparison with more detailed Mie scattering theory using an ensemble of spherical dielectric scatterers. Modest differences are found between the two prescription for describing photon angular scattering in tissue. In particular, the Mie scattering phase functions provide less overall reflectance signal but more signal contrast compared to the Henyey-Greenstein formulation.

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Peter A. Amendt, Kent G. Estabrook, Matthew J. Everett, Richard A. London, Duncan J. Maitland, George B. Zimmerman, Bill W. Colston Jr., Luiz Barroca Da Silva, and Ujwal S. Sathyam "Monte-Carlo simulations of arterial imaging with optical coherence tomography", Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); https://doi.org/10.1117/12.384157

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KEYWORDS

Scattering

Optical coherence tomography

Mie scattering

Monte Carlo methods

Laser scattering

Photon transport

Signal detection

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