Monitoring of laser treatment of rat tumors using digital x-ray imaging technique

Wei R. Chen; Hong Liu; Robert E. Nordquist

doi:10.1117/12.466640

13 May 2002 Monitoring of laser treatment of rat tumors using digital x-ray imaging technique

Wei R. Chen, Hong Liu, Robert E. Nordquist

Proceedings Volume 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV; (2002) https://doi.org/10.1117/12.466640
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

An optically coupled CCD digital x-ray imaging system was used in monitoring laser immunotherapy treatment of a metastatic breast tumor in rats. The treatment modality involved an intratumor injection of photosensitizer and immunoadjuvant, followed by a noninvasive irradiation of an 805-nm diode laser using a multiple fiber delivery device designed to facilitate deep laser energy penetration. The high resolution digital x-ray imaging system acquired rat images following the intratumor injection of the photosensitizer and immunoadjuvant in an attempt to determine their distribution inside the tumor and in the surrounding normal tissue. The change of the transmitted x- ray signal due to photosensitizer/immunoadjuvant injection could be clearly differentiated using the x-ray images. Digital x-ray images of treated tumors were obtained during the laser treatment. The dynamic observation showed that the photothermal reaction in tumors by the combination of the in situ laser-absorbing dye and the laser energy caused a quick increase of x-ray signals, while the x-ray signals in the tissue without dye remained relatively unchanged during the treatment. The distribution of the injected drugs and the near-real-time x-ray signal change in tissue during laser treatment could be used to optimize the treatment parameters. Our results indicate that x-ray image guided laser treatment of deep tumors is highly feasible.

Citation Download Citation

Wei R. Chen, Hong Liu, and Robert E. Nordquist "Monitoring of laser treatment of rat tumors using digital x-ray imaging technique", Proc. SPIE 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, (13 May 2002); https://doi.org/10.1117/12.466640

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KEYWORDS

Tumors

X-rays

Laser therapeutics

Laser tissue interaction

X-ray imaging

Charge-coupled devices

Tissues

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