Thermal imaging of brain tumors in a rat glioma model

Thanassis Papaioannou; Reid C. Thompson; Babak Kateb; Oleg Sorokoumov M.D.; Warren S. Grundfest M.D.; Keith L. Black

doi:10.1117/12.466653

13 May 2002 Thermal imaging of brain tumors in a rat glioma model

Thanassis Papaioannou, Reid C. Thompson, Babak Kateb, Oleg Sorokoumov M.D., Warren S. Grundfest M.D., Keith L. Black

Proceedings Volume 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV; (2002) https://doi.org/10.1117/12.466653
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

We have explored the capability of thermal imaging for the detection of brain tumors in a rat glioma mode. Fourteen Wistar rats were injected stereotactically with 100,000 C6 glioma cells. Approximately one and two weeks post implantation, the rats underwent bilateral craniotomy and the exposed brain surface was imaged with a short wave thermal camera. Thermal images were obtained at both low (approximately 28.7 degree(s)C) and high (approximately 38 degree(s)C) core temperatures. Temperature gradients between the tumor site and the contralateral normal brain were calculated. Overall, the tumors appeared cooler than normal brain, for both high and low core temperatures. Average temperature difference between tumor and normal brain were maximal in more advanced tumors (two weeks) and at higher core temperatures. At one week (N equals 6), the average temperature gradient between tumor and normal sites was 0.1 degree(s)C and 0.2 degree(s)C at low and high core temperatures respectively (P(greater than)0.05). At two weeks (N equals 8), the average temperature gradient was 0.3 degree(s)C and 0.7 degree(s)C at low and high core temperatures respectively (P<0.05). We conclude that thermal imaging can detect temperature differences between tumor and normal brain tissue in this model, particularly in more advanced tumors. Thermal imaging may provide a novel means to identify brain tumors intraoperatively.

Citation Download Citation

Thanassis Papaioannou, Reid C. Thompson, Babak Kateb, Oleg Sorokoumov M.D., Warren S. Grundfest M.D., and Keith L. Black "Thermal imaging of brain tumors in a rat glioma model", Proc. SPIE 4615, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems IV, (13 May 2002); https://doi.org/10.1117/12.466653

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