Photodynamic therapy of breast cancer with photosense

Elena G. Vakoulovskaya M.D.; Victor V. Shental M.D.; Loubov V. Oumnova; Georgiu N. Vorozhcsov

doi:10.1117/12.479431

13 June 2003 Photodynamic therapy of breast cancer with photosense

Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., Loubov V. Oumnova, Georgiu N. Vorozhcsov

Author Affiliations +

Proceedings Volume 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII; (2003) https://doi.org/10.1117/12.479431
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Photodynamic Therapy (PDT) using photosensitizer Photosense (PS) in dose 0.5 mg per kg of body weight have been provided in 24 patients with breast cancer. In 22 patients with T1-T2N0M0 primary tumor was treated as the preoperative treatment, radical mastectomy has been fulfilled 7-10 days after PDT with subsequent histological examination. 2 patients had recurrencies of breast cancer with lymph node metastases after radiotherapy. Fluorescent diagnostics of tumor, accumulation of PS in tumor, adjacent tissue, skin before and during PDT was fulfilled with spectranalyzer LESA-01. We used semiconductive laser for PDT - λ = 672+2nm, P=1,5 W, interstitial irradiation 2-24 hours after PS injection has been done in light dose 150-200 J/cm3, 1-3 irradiations with interval 24-48 hours and total light dose 400-600 J/cm3 depending mostly of size and fluorescent data. Partial regression of tumor with pathomorphosis of 2-4 degrees has been found in 19 cases. Our experience shows pronounced efficacy of PDT for treating breast cancer as preoperative modality and as palliation in cases of recurrencies.

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Elena G. Vakoulovskaya M.D., Victor V. Shental M.D., Loubov V. Oumnova, and Georgiu N. Vorozhcsov "Photodynamic therapy of breast cancer with photosense", Proc. SPIE 4952, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII, (13 June 2003); https://doi.org/10.1117/12.479431

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