The thermal dissociation of cholesterol esters using a 5.75-&#956;m free-electron laser

Yuko Fukami; Kunio Awazu

doi:10.1117/12.477690

27 August 2003 The thermal dissociation of cholesterol esters using a 5.75-μm free-electron laser

Yuko Fukami, Kunio Awazu

Proceedings Volume 4961, Laser-Tissue Interaction XIV; (2003) https://doi.org/10.1117/12.477690
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

In order to estimate the optimum laser conditions for efficient dissociation of cholesterol ester in an arteriosclerotic region of blood vessels, we have invstigated the relationship between laser wavelength and power density on cholesterol ester dissociation using a mid infrared free electron laser (MIR-FEL). In this study, cholesteryl oleate, which is a typical cholesterol ester found in arteriosclerotic regions, was irradited with 5.75-μm-FELs, which cause vibration of ester bonds. Two results were obtained. (1) Ester dissociated depending on the absorption coefficient, and the macropulse duration was shorter than the thermal relaxation time, showing that ester bonds dissociated into carboxylic acid and cholesterol by macropulse-induced thermal effects without accompanying thermal diffusion, (2) Using a wavelength of 5.75-μm the maximum ester dissociation ratio was achieved under the optimum laser conditions of a macropulse energy density of 0.4-1.0 J/cm². We conclude that MIR pulsed-lasers with a wavelegnth of 5.75 μm can be useful for removal of cholesteryl lester in an arteriosclerotic region of blood vessels.

Citation Download Citation

Yuko Fukami and Kunio Awazu "The thermal dissociation of cholesterol esters using a 5.75-μm free-electron laser", Proc. SPIE 4961, Laser-Tissue Interaction XIV, (27 August 2003); https://doi.org/10.1117/12.477690

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