Optical characterization of small biopsy samples

Anikitos Garofalakis; Giannis Zacharakis; George Filippidis; Elias Sanidas; Dimitris D Tsiftsis; Eleftherios N Stathopoulos; Maria Kafousi; Theodore G. Papazoglou; Jorge Ripoll

doi:10.1117/12.500546

8 October 2003 Optical characterization of small biopsy samples

Anikitos Garofalakis, Giannis Zacharakis, George Filippidis, Elias Sanidas, Dimitris D Tsiftsis, Eleftherios N Stathopoulos, Maria Kafousi, Theodore G. Papazoglou, Jorge Ripoll

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Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500546
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Optical characterization of biopsies can be used to discern between tissues when performing diffuse optical tomography of the female breast. The theory used for deriving the optical properties of such highly scattering media is based on the diffusion approximation. However, focusing the study in the regime of geometries comparable to the scattering mean free path, the diffusion approximation must be rearranged. Here we present several theoretical assumptions in this direction. In order to investigate the validity of the improved theory, experiments were made involving the transmittance of laser light through turbid phantom models. After the validation of our theoretical model, we have managed to derive the optical properties of over 50 excised breast tissue samples.

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Anikitos Garofalakis, Giannis Zacharakis, George Filippidis, Elias Sanidas, Dimitris D Tsiftsis, Eleftherios N Stathopoulos, Maria Kafousi, Theodore G. Papazoglou, and Jorge Ripoll "Optical characterization of small biopsy samples", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500546

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KEYWORDS

Tissues

Scattering

Diffusion

Biopsy

Tumors

Breast

Optical properties

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