Thermal fixation: a central outcome of hyperthermic therapies

James E. Coad M.D.

doi:10.1117/12.591175

14 April 2005 Thermal fixation: a central outcome of hyperthermic therapies (Invited Paper)

James E. Coad M.D.

Proceedings Volume 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III; (2005) https://doi.org/10.1117/12.591175
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Currently, several minimally invasive hyperthermic-based surgical technologies are available for the treatment of dysfunctional and neoplastic tissues in a variety of organ systems. These therapies involve a number of different modalities for delivering heat energy to the target tissue, including radiofrequency/microwave, conductive/convective, loop resection, and others. Despite differences in energy transfer and organ system treated, hyperthermic lesions often have a multiregional architecture with a central thermal fixation region, adjacent middle coagulative-type necrosis region, and outer transitional region of variable cell injury/death. The regional percentages of these components vary depending on the overall thermal history distribution across the lesion. The thermal-fixed region generally lacks a wound healing response, resists breakdown/tissue repair, and may elicit a localized foreign body-type reaction. The other two regions generally undergo wound healing/repair with scar formation. The features of thermal fixation are highlighted and explored through several histopathologic case vignettes.

Citation Download Citation

James E. Coad M.D. "Thermal fixation: a central outcome of hyperthermic therapies (Invited Paper)", Proc. SPIE 5698, Thermal Treatment of Tissue: Energy Delivery and Assessment III, (14 April 2005); https://doi.org/10.1117/12.591175

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