Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system

Nzola De Magalhães; Lih-Huei L. Liaw; Linda Li; Angela Liogys; Steen J. Madsen; Henry Hirschberg M.D.; Bruce J. Tromberg

doi:10.1117/12.668795

22 February 2006 Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system

Nzola De Magalhães, Lih-Huei L. Liaw, Linda Li, Angela Liogys, Steen J. Madsen, Henry Hirschberg M.D., Bruce J. Tromberg

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Proceedings Volume 6078, Photonic Therapeutics and Diagnostics II; 607830 (2006) https://doi.org/10.1117/12.668795
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

An in-vivo tumor model composed of multicellular human glioma spheroids implanted on a shell-less chorioallantoic membrane (CAM), has been developed. Following removal of a portion of the ectodermal epithelium layer of the CAM, human glioma spheroids were implanted on day 7 of embryonic development. Tumor invasion, rapid growth and vasculature formation were observed 7 days post implantation. Single tumor cell migration towards blood vessels, angiogenesis and satellite tumor growth were also evident. The human tumor/CAM model is being used to examine the effects of combined ALA PDT and anti-angiogenic agents. The shell-less CAM is well suited for topical, i.p. and i.v. photosensitizer and/or drug application.

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Nzola De Magalhães, Lih-Huei L. Liaw, Linda Li, Angela Liogys, Steen J. Madsen, Henry Hirschberg M.D., and Bruce J. Tromberg "Investigating the effects of combined photodynamic and anti-angiogenic therapies using a three-dimensional in vivo brain tumor system", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 607830 (22 February 2006); https://doi.org/10.1117/12.668795

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