Statistical parametric mapping for in vivo MRI assessment of morphological changes in rat articular cartilage

Ping Chiao; Zhiyong Xie; Shantanu Dhamija; Serguei Liachenko; Michael Gieseg

doi:10.1117/12.650625

13 March 2006 Statistical parametric mapping for in vivo MRI assessment of morphological changes in rat articular cartilage

Ping Chiao, Zhiyong Xie, Shantanu Dhamija, Serguei Liachenko, Michael Gieseg

Author Affiliations +

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 614326 (2006) https://doi.org/10.1117/12.650625
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

This paper explores the use of statistical parametric mapping, which has been widely used in brain imaging applications, in the assessment of morphological changes in rat articular cartilage during OA. This approach can not only detect but also localize changes, effectively zooming in statistically more informative areas and therefore maximizing the sensitivity. The analysis of in-vivo MR images of rat articular cartilage demonstrates that the new approach is at least as sensitive as the cartilage volume analysis.

Citation Download Citation

Ping Chiao, Zhiyong Xie, Shantanu Dhamija, Serguei Liachenko, and Michael Gieseg "Statistical parametric mapping for in vivo MRI assessment of morphological changes in rat articular cartilage", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 614326 (13 March 2006); https://doi.org/10.1117/12.650625

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