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23 March 2007 Mapping tissue chromophore changes in cerebral ischemia: a pilot study
David Abookasis, Marlon S. Mathews M.D., Christopher Lay, David J. Cuccia, Ron D. Frostig, Mark E. Linskey M.D., Bruce J. Tromberg
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Proceedings Volume 6424, Photonic Therapeutics and Diagnostics III; 64242J (2007) https://doi.org/10.1117/12.718430
Event: SPIE BiOS, 2007, San Jose, California, United States
Abstract
We describe the projection of spatially modulated light for quantitatively mapping changes in oxyhemoglobin, deoxyhemoglobin, and oxygen saturation in two pilot studies in the rat barrel cortex during both permanent and temporary cerebral ischemia. The approach is based on the projection of spatial modulation of white light onto the brain. The reflected light is captured on a CCD camera, which is then processed to obtain the concentration and distribution of chromophores over a wide field. Preliminary results confirm a measurable and quantifiable increase in tissue molecular concentration of deoxy-hemoglobin and decrease in hemoglobin oxygen concentration in both experimental settings. Our preliminary data from our pilot studies demonstrate that spatial modulation of light can provide quantitative chromophore mapping of the brain and has a potential role in monitoring the course and severity of cerebral ischemia in cerebrovascular disease patients.
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David Abookasis, Marlon S. Mathews M.D., Christopher Lay, David J. Cuccia, Ron D. Frostig, Mark E. Linskey M.D., and Bruce J. Tromberg "Mapping tissue chromophore changes in cerebral ischemia: a pilot study", Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64242J (23 March 2007); https://doi.org/10.1117/12.718430
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KEYWORDS
Brain
Chromophores
Ischemia
Brain mapping
Modulation
Oxygen
Tissues
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