Clinical data analysis for the combined optical and tomosynthesis breast imaging

Qianqian Fang; Juliette Selb; Stefan A. Carp; Greg Boverman; Daniel B. Kopans; Richard H. Moore; David A. Boas

doi:10.1117/12.701623

20 February 2007 Clinical data analysis for the combined optical and tomosynthesis breast imaging

Qianqian Fang, Juliette Selb, Stefan A. Carp, Greg Boverman, Daniel B. Kopans, Richard H. Moore, David A. Boas

Proceedings Volume 6431, Multimodal Biomedical Imaging II; 64310H (2007) https://doi.org/10.1117/12.701623
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Combining 2D X-ray mammography or 3D tomosynthesis with diffuse optical tomography for breast imaging is advantageous in facilitating clinical diagnosis by fusing the structural X-ray images with functional optical images. In this study, we imaged 65 patients with a combined tomosynthesis/diffuse optical breast imaging system developed at Massachusetts General Hospital. The bulk optical properties and patient demographics were summarized in this paper. The averaged total-hemoglobin for 60 healthy breasts is 21 &mgr;M which is comparable with literature values given the applied mammographic compression in our experiments. The averaged oxygen saturation is 76%. The comparison of contra-lateral breast measurements also demonstrated correlations in total hemoglobin and oxygen saturation. Image reconstructions of the healthy breasts with moderate-sized fibroglandular regions correctly recovered the chest-wall muscle, fibro-glandular tissue as well as the surrounding fatty tissue. For dense breasts, the contrast between the chest-wall and the fibro-glandular region is small and the most pronounced feature of the image is a low-absorption region in the center of the breast. We hypothesized that this is caused by pressure induced blood-redistribution. Supportive evidence for this hypothesis had been shown with mechanical simulations of breast compression.

Citation Download Citation

Qianqian Fang, Juliette Selb, Stefan A. Carp, Greg Boverman, Daniel B. Kopans, Richard H. Moore, and David A. Boas "Clinical data analysis for the combined optical and tomosynthesis breast imaging", Proc. SPIE 6431, Multimodal Biomedical Imaging II, 64310H (20 February 2007); https://doi.org/10.1117/12.701623

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