Integrated visualization of multi-angle bioluminescence imaging and micro CT

P. Kok; J. Dijkstra; C. P. Botha; F. H. Post; E. Kaijzel; I. Que; C. W. G. M. Löwik; J. H. C. Reiber; B. P. F. Lelieveldt

doi:10.1117/12.711117

22 March 2007 Integrated visualization of multi-angle bioluminescence imaging and micro CT

P. Kok, J. Dijkstra, C. P. Botha, F. H. Post, E. Kaijzel, I. Que, C. W. G. M. Löwik, J. H. C. Reiber, B. P. F. Lelieveldt

Author Affiliations +

Proceedings Volume 6509, Medical Imaging 2007: Visualization and Image-Guided Procedures; 65091U (2007) https://doi.org/10.1117/12.711117
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

This paper explores new methods to visualize and fuse multi-2D bioluminescence imaging (BLI) data with structural imaging modalities such as micro CT and MR. A geometric, back-projection-based 3D reconstruction for superficial lesions from multi-2D BLI data is presented, enabling a coarse estimate of the 3D source envelopes from the multi-2D BLI data. Also, an intuitive 3D landmark selection is developed to enable fast BLI / CT registration. Three modes of fused BLI / CT visualization were developed: slice visualization, carousel visualization and 3D surface visualization. The added value of the fused visualization is demonstrated in three small-animal experiments, where the sensitivity of BLI to detect cell clusters is combined with anatomical detail from micro-CT imaging.

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P. Kok, J. Dijkstra, C. P. Botha, F. H. Post, E. Kaijzel, I. Que, C. W. G. M. Löwik, J. H. C. Reiber, and B. P. F. Lelieveldt "Integrated visualization of multi-angle bioluminescence imaging and micro CT", Proc. SPIE 6509, Medical Imaging 2007: Visualization and Image-Guided Procedures, 65091U (22 March 2007); https://doi.org/10.1117/12.711117

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