3D bioluminescent source localization of different depths with spectrum information and adaptive finite element analysis

Yujie Lv; Jie Tian; Wenxiang Cong; Ge Wang; Wei Yang; Min Xu

doi:10.1117/12.709018

13 March 2007 3D bioluminescent source localization of different depths with spectrum information and adaptive finite element analysis

Yujie Lv, Jie Tian, Wenxiang Cong, Ge Wang, Wei Yang, Min Xu

Author Affiliations +

Proceedings Volume 6510, Medical Imaging 2007: Physics of Medical Imaging; 651025 (2007) https://doi.org/10.1117/12.709018
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

In this contribution, a novel adaptive finite element based source localization method is proposed and developed, which adopts the spectrum characteristic of bioluminescent source. In this method, multiple sets of surface measured data corresponding to the discretized spectral bands reduce the ill-posedness of BLT. Then, the adaptive mesh refinement using a posteriori error estimation helps not only to avoid the dimension disaster arisen from the multi-spectral measured data, but also to improve the BLT reconstruction. In addition, a posteriori permissible source region selection further reduces the ill-posedness of BLT and enhances the reconstruction stability and speed. Finally, the simulation verification of the proposed method is performed with the Monte Carlo (MC) based synthetic data. The accurate localization of one and two bioluminescent sources in different depths shows the effectiveness and potential of this algorithm for BLT.

Citation Download Citation

Yujie Lv, Jie Tian, Wenxiang Cong, Ge Wang, Wei Yang, and Min Xu "3D bioluminescent source localization of different depths with spectrum information and adaptive finite element analysis", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 651025 (13 March 2007); https://doi.org/10.1117/12.709018

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