Improved electrochemical biosensor response via metal oxide pre-oxidation of chemical interferents

Jamie G. Houseknecht; Mark A. Tapsak

doi:10.1117/12.752637

25 September 2007 Improved electrochemical biosensor response via metal oxide pre-oxidation of chemical interferents

Jamie G. Houseknecht, Mark A. Tapsak

Proceedings Volume 6769, Nanosensing: Materials, Devices, and Systems III; 67690I (2007) https://doi.org/10.1117/12.752637
Event: Optics East, 2007, Boston, MA, United States

Abstract

Typical biological samples are inherently complicated. They may contain a myriad of compounds that are electroactive at the same potential as that used in many electrochemical biosensors. Therefore, a biosensor design feature must be included that either eliminates or blocks the interferents from generating false positive signals. The ability to use an insoluble compound, that of MnO₂, in order to oxidize interferents such as ascorbic acid, acetaminophen and uric acid, was investigated in a prototype sensor system at a bias potential of 0.6 V versus Ag/AgCl. Unlike previous work with these materials, a difference between the ability for the metal oxide to oxidize the interferents was observed. Most effective was the capability of MnO₂ to oxidize uric acid. Alternatively, the MnO₂ had little effect on acetaminophen. The study is both introduced and results are discussed within the context of an implantable glucose sensor.

Citation Download Citation

Jamie G. Houseknecht and Mark A. Tapsak "Improved electrochemical biosensor response via metal oxide pre-oxidation of chemical interferents", Proc. SPIE 6769, Nanosensing: Materials, Devices, and Systems III, 67690I (25 September 2007); https://doi.org/10.1117/12.752637

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