Paper
12 March 2008 Fast 3D fluid registration of brain magnetic resonance images
Natasha Leporé, Yi-Yu Chou, Oscar L. Lopez, Howard J. Aizenstein, James T. Becker, Arthur W. Toga, Paul M. Thompson
Author Affiliations +
Abstract
Fluid registration is widely used in medical imaging to track anatomical changes, to correct image distortions, and to integrate multi-modality data. Fluid mappings guarantee that the template image deforms smoothly into the target, without tearing or folding, even when large deformations are required for accurate matching. Here we implemented an intensity-based fluid registration algorithm, accelerated by using a filter designed by Bro-Nielsen and Gramkow. We validated the algorithm on 2D and 3D geometric phantoms using the mean square difference between the final registered image and target as a measure of the accuracy of the registration. In tests on phantom images with different levels of overlap, varying amounts of Gaussian noise, and different intensity gradients, the fluid method outperformed a more commonly used elastic registration method, both in terms of accuracy and in avoiding topological errors during deformation. We also studied the effect of varying the viscosity coefficients in the viscous fluid equation, to optimize registration accuracy. Finally, we applied the fluid registration algorithm to a dataset of 2D binary corpus callosum images and 3D volumetric brain MRIs from 14 healthy individuals to assess its accuracy and robustness.
© (2008) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Natasha Leporé, Yi-Yu Chou, Oscar L. Lopez, Howard J. Aizenstein, James T. Becker, Arthur W. Toga, and Paul M. Thompson "Fast 3D fluid registration of brain magnetic resonance images", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69160Z (12 March 2008); https://doi.org/10.1117/12.774338
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Cited by 22 scholarly publications.
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KEYWORDS
Image registration

3D image processing

Brain

Neuroimaging

Magnetic resonance imaging

3D acquisition

Detection and tracking algorithms

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