Surface-enhanced Raman spectroscopy study of the interaction of antitumoral drug Paclitaxel with human serum albumin

Tianxiu Yan; Huaimin Gu; Xiaojuan Yuan; Jiwei Wu; Huajiang Wei

doi:10.1117/12.821462

6 March 2009 Surface-enhanced Raman spectroscopy study of the interaction of antitumoral drug Paclitaxel with human serum albumin

Tianxiu Yan, Huaimin Gu, Xiaojuan Yuan, Jiwei Wu, Huajiang Wei

Author Affiliations +

Proceedings Volume 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine; 72800N (2009) https://doi.org/10.1117/12.821462
Event: Photonics and Optoelectronics Meetings, 2008, Wuhan, China

Abstract

SERS spectroscopy was employed to study the interaction of the antitumoral drug paclitaxel with human serum albumin. The normal Raman spectrum of the paclitaxel was shown in this study for the first time. There were some differences existing in the surface-enhanced Raman scattering (SERS) spectrum of paclitaxel and its human serum albumin (HSA), which demonstrated that there was high bioaffinity of paclitaxel to human serum albumin. And it was also found that there existed some differences in the SERS of the paclitaxel/HSA complexes at different pH values, which may indicated some significant information on the binding site, by which paclitaxel binds to human serum albumin. It can provide significant instruction in the synthesis of the drug and in improving the therapeutic efficacy of this drug.

Citation Download Citation

Tianxiu Yan, Huaimin Gu, Xiaojuan Yuan, Jiwei Wu, and Huajiang Wei "Surface-enhanced Raman spectroscopy study of the interaction of antitumoral drug Paclitaxel with human serum albumin", Proc. SPIE 7280, Seventh International Conference on Photonics and Imaging in Biology and Medicine, 72800N (6 March 2009); https://doi.org/10.1117/12.821462

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