Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy

Huan-Yao Lei; Ching-An Peng; Ming-Jer Tang M.D.; Kit Reindhart; Harold H. Szu

doi:10.1117/12.820838

19 March 2009 Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy

Huan-Yao Lei, Ching-An Peng, Ming-Jer Tang M.D., Kit Reindhart, Harold H. Szu

Proceedings Volume 7343, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VII; 73430Q (2009) https://doi.org/10.1117/12.820838
Event: SPIE Defense, Security, and Sensing, 2009, Orlando, Florida, United States

Abstract

Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of Con_A can eradicate the established malign tumor, because Con_A can induce tumor cell autophagic, cell-programmed death, as well as activate the effector T cells. Combined, in this paper, with the absorption exceeding the Carbon NanoTube (CNT) band-gap (εbg=~1/CNT diameter) with an active short wave near-infrared (SWIR) (1.2~1.5 micron wavelengths), which happened to be translucent to the irradiation upon animal skin, similar to that used in hospital fingertip-clamped Pulse Oxymetry. Once the Con_ACNT is guided to hepatoma cells, it is bonded and internalized into the mitochondria (MC) compartment, the cellular energy factory. Con_A has the higher specificity for tumor cells useful for targeting because of the abnormal glycosylation on tumor cells. When CNT hitch hike with Con_A, they can t together like a laser-denotable chemical missile surgically targeting at the tumor cells precisely by Con_A-guidance. We switch on SWIR laser, when the Con_A-CNT conjugated complex has been bonded and internalized to MC of malign cells and already commenced cellular programmed death. Thus, it might appear to casual readers that we have initiated an overkill, chemical drugged autophage followed with physical laser ablation, but what if we can eradicate hepatoma totally if no blue print is left behind inadvertently in case of a partial failure. We conclude that using Con_A-CNT conjugated complex targeting specifically at malign tumor cells is a novel targeted-laser-radiation therapy for tumors in mice.

Citation Download Citation

Huan-Yao Lei, Ching-An Peng, Ming-Jer Tang M.D., Kit Reindhart, and Harold H. Szu "Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy", Proc. SPIE 7343, Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VII, 73430Q (19 March 2009); https://doi.org/10.1117/12.820838

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