The implementation of an isotope-edited internal standard for quantification of lowest drug concentrations using surface enhanced Raman spectroscopy (SERS) in a lab on a chip device

Anne März; Petra Rösch; Thomas Henkel; Jürgen Popp

doi:10.1117/12.831619

7 July 2009 The implementation of an isotope-edited internal standard for quantification of lowest drug concentrations using surface enhanced Raman spectroscopy (SERS) in a lab on a chip device

Anne März, Petra Rösch, Thomas Henkel, Jürgen Popp

Author Affiliations +

Proceedings Volume 7368, Clinical and Biomedical Spectroscopy; 73680R (2009) https://doi.org/10.1117/12.831619
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

The application of surface enhanced Raman spectroscopy in combination with a microfluidic device and an isotopeedited internal standard seems to be a promising way for a new approach for quantitative SERS measurements. An innovative lab on a chip system offers the possibility for reproducible, quantitative online SERS measurements based on the application of isotope labelled internal standards and liquid/liquid segmented flow based flow-through Raman detection. Errors caused by the used method can be compensated by using an internal standard.

Citation Download Citation

Anne März, Petra Rösch, Thomas Henkel, and Jürgen Popp "The implementation of an isotope-edited internal standard for quantification of lowest drug concentrations using surface enhanced Raman spectroscopy (SERS) in a lab on a chip device", Proc. SPIE 7368, Clinical and Biomedical Spectroscopy, 73680R (7 July 2009); https://doi.org/10.1117/12.831619

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