Polarization sensitive optical coherence tomography of melanin provides tissue inherent contrast based on depolarization

Bernhard Baumann; Stefan O. Baumann; Thomas Konegger; Michael Pircher; Erich Götzinger; Harald Sattmann; Marco Litschauer; Christoph K. Hitzenberger

doi:10.1117/12.843226

19 February 2010 Polarization sensitive optical coherence tomography of melanin provides tissue inherent contrast based on depolarization

Bernhard Baumann, Stefan O. Baumann, Thomas Konegger, Michael Pircher, Erich Götzinger, Harald Sattmann, Marco Litschauer, Christoph K. Hitzenberger

Author Affiliations +

Proceedings Volume 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV; 75541M (2010) https://doi.org/10.1117/12.843226
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Polarization sensitive optical coherence tomography (PS-OCT) was used to investigate the polarization properties of melanin. Measurements in samples with varying melanin concentrations revealed polarization scrambling, i.e. depolarization. The results indicate that the depolarizing appearance of pigmented structures like, for instance, the retinal pigment epithelium (RPE) is likely to be caused by the melanin granules contained in these cells.

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Bernhard Baumann, Stefan O. Baumann, Thomas Konegger, Michael Pircher, Erich Götzinger, Harald Sattmann, Marco Litschauer, and Christoph K. Hitzenberger "Polarization sensitive optical coherence tomography of melanin provides tissue inherent contrast based on depolarization", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 75541M (19 February 2010); https://doi.org/10.1117/12.843226

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