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A recently developed "in vivo flow cytometer" and optical imaging are used to assess liver tumor cell spreading and the
circulation kinetics of liver tumor cells. The in vivo flow cytometer has the capability to detect and quantify the number
and flow characteristics of fluorescently labeled cells in vivo continuously. The depletion rate of circulating tumor cells
provides insights in early cancer metastasis. It is useful to understand the molecular mechanisms of liver tumor
metastasis. A real-time quantitative monitoring of circulating liver tumor cells by the in vivo flow cytometer will help
assess the effectiveness of the potential therapeutic interventions.
Yan Li,Jin Guo,Guangda Liu,Chen Wang,Zhengqin Gu, andXunbin Wei
"Monitoring hepatocellular carcinoma metastasis by in vivo flow cytometer", Proc. SPIE 7565, Biophotonics and Immune Responses V, 75650D (11 February 2010); https://doi.org/10.1117/12.843459
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Yan Li, Jin Guo, Guangda Liu, Chen Wang, Zhengqin Gu, Xunbin Wei, "Monitoring hepatocellular carcinoma metastasis by in vivo flow cytometer," Proc. SPIE 7565, Biophotonics and Immune Responses V, 75650D (11 February 2010); https://doi.org/10.1117/12.843459