Gold nanorods for applications in biological imaging

Y. Zhang; J. Yu; D. J. S. Birch; Y. Chen

doi:10.1117/12.877156

11 February 2011 Gold nanorods for applications in biological imaging

Y. Zhang, J. Yu, D. J. S. Birch, Y. Chen

Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 79101H (2011) https://doi.org/10.1117/12.877156
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Two-Photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging for high resolution, low photo-damage, tunable near infra-red (NIR) longitudinal band, polarization dependence, ability to conjugate to bio-molecules and low toxicity. Here we demonstrate the application of gold nanorods as TPL imaging agents by studying the gold nanorods taken up by Madin-Darby canine kidney (MDCK) cells using both confocal imaging and fluorescence lifetime imaging microscopy (FLIM). The characteristic luminescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.

Citation Download Citation

Y. Zhang, J. Yu, D. J. S. Birch, and Y. Chen "Gold nanorods for applications in biological imaging", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101H (11 February 2011); https://doi.org/10.1117/12.877156

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