In vivo heterogeneous tomographic bioluminescence imaging via a higher-order approximation forward model

Kai Liu; Jie Tian Sr.; Chenghu Qin; Xin Yang; Shouping Zhu; Dong Han; Ping Wu; Xiaoqian Dai

doi:10.1117/12.878040

9 March 2011 In vivo heterogeneous tomographic bioluminescence imaging via a higher-order approximation forward model

Kai Liu, Jie Tian Sr., Chenghu Qin, Xin Yang, Shouping Zhu, Dong Han, Ping Wu, Xiaoqian Dai

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79650C (2011) https://doi.org/10.1117/12.878040
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

In vivo bioluminescence imaging (BLI) has played a more and more important role in biomedical research of small animals. Tomographic bioluminescence imaging (TBI) further translates the BLI optical information into three-dimensional bioluminescent source distribution, which could greatly facilitate applications in related studies. Although the diffusion approximation (DA) is one of the most widely-used forward models, higher-order approximations are still needed for in vivo small animal imaging. In this work, as a relatively accurate and higher-order approximation theory, a simplified spherical harmonics approximation (SP_N) is applied for heterogeneous tomographic bioluminescence imaging in vivo. Furthermore, coupled with the SP_N, a generalized graph cuts optimization approach is utilized, making BLT reconstructions fast and suit for the whole body of small animals. Heterogeneous in vivo experimental reconstructions via the higher-order approximation model demonstrate higher tomographic imaging quality, which is shown the capability for practical biomedical tomographic imaging applications.

Citation Download Citation

Kai Liu, Jie Tian Sr., Chenghu Qin, Xin Yang, Shouping Zhu, Dong Han, Ping Wu, and Xiaoqian Dai "In vivo heterogeneous tomographic bioluminescence imaging via a higher-order approximation forward model", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650C (9 March 2011); https://doi.org/10.1117/12.878040

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