Near-infrared imaging spectroscopy for counterfeit drug detection

Thomas Arnold; Martin De Biasio; Raimund Leitner

doi:10.1117/12.884732

12 May 2011 Near-infrared imaging spectroscopy for counterfeit drug detection

Thomas Arnold, Martin De Biasio, Raimund Leitner

Proceedings Volume 8032, Next-Generation Spectroscopic Technologies IV; 80320Y (2011) https://doi.org/10.1117/12.884732
Event: SPIE Defense, Security, and Sensing, 2011, Orlando, Florida, United States

Abstract

Pharmaceutical counterfeiting is a significant issue in the healthcare community as well as for the pharmaceutical industry worldwide. The use of counterfeit medicines can result in treatment failure or even death. A rapid screening technique such as near infrared (NIR) spectroscopy could aid in the search for and identification of counterfeit drugs. This work presents a comparison of two laboratory NIR imaging systems and the chemometric analysis of the acquired spectroscopic image data. The first imaging system utilizes a NIR liquid crystal tuneable filter and is designed for the investigation of stationary objects. The second imaging system utilizes a NIR imaging spectrograph and is designed for the fast analysis of moving objects on a conveyor belt. Several drugs in form of tablets and capsules were analyzed. Spectral unmixing techniques were applied to the mixed reflectance spectra to identify constituent parts of the investigated drugs. The results show that NIR spectroscopic imaging can be used for contact-less detection and identification of a variety of counterfeit drugs.

Citation Download Citation

Thomas Arnold, Martin De Biasio, and Raimund Leitner "Near-infrared imaging spectroscopy for counterfeit drug detection", Proc. SPIE 8032, Next-Generation Spectroscopic Technologies IV, 80320Y (12 May 2011); https://doi.org/10.1117/12.884732

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