Poly(dimethylsiloxane) photonic microbioreactors and multiple internal reflection systems for real time cell screening

Pedro Ortiz; Stefanie Demming; Elisabet Fernández-Rosas; Bergoi Ibarlucea; Jordi Vila-Planas; Stephanus Büttgenbach; Andreu Llobera

doi:10.1117/12.889671

5 May 2011 Poly(dimethylsiloxane) photonic microbioreactors and multiple internal reflection systems for real time cell screening

Pedro Ortiz, Stefanie Demming, Elisabet Fernández-Rosas, Bergoi Ibarlucea, Jordi Vila-Planas, Stephanus Büttgenbach, Andreu Llobera

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Proceedings Volume 8066, Smart Sensors, Actuators, and MEMS V; 80660D (2011) https://doi.org/10.1117/12.889671
Event: SPIE Microtechnologies, 2011, Prague, Czech Republic

Abstract

In this paper two different photonic lab-on-a-chip devices for real-time cell screening are presented. We discuss, in parallel, screening of cell viability and cell count using a multiple total internal reflection (MIR) system, and a microbioreactor (MBR) for continuous cell culture screening. Each device takes advantage, in different ways, of the enhanced light-analyte interaction provided by the full-field approach. Their performance and how they represent an improvement to current methods, are also discussed herein. Both devices integrate photonic components and are fabricated by soft lithography (PDMS) replica molding of SU-8 masters, thus making them low-cost and easily mass produced.

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Pedro Ortiz, Stefanie Demming, Elisabet Fernández-Rosas, Bergoi Ibarlucea, Jordi Vila-Planas, Stephanus Büttgenbach, and Andreu Llobera "Poly(dimethylsiloxane) photonic microbioreactors and multiple internal reflection systems for real time cell screening", Proc. SPIE 8066, Smart Sensors, Actuators, and MEMS V, 80660D (5 May 2011); https://doi.org/10.1117/12.889671

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