|
In recent years, using the detection of interstitial fluid glucose concentration to realize the real-time continuous
monitoring of blood glucose concentration gets more and more attention, because for one person, the relationship
between blood glucose concentration and interstitial fluid glucose concentration satisfies specific rules. However, the
glucose concentration in interstitial fluid is not entirely equal to the glucose concentration in blood and has a
physiological lag because of the physiological difference of cells in blood and interstitial fluid. Because the clinical
diagnostic criteria of diabetes are still blood glucose concentration, the evaluation model of the physiological lag
parameter between the glucose concentration in blood and the glucose concentration in interstitial fluid should be
established. The physiological difference in glucose molecules uptake, utilization, and elimination by cells in blood and
interstitial fluid and the diffusion velocity of glucose molecule from blood to interstitial fluid will be induced to the mass
transfer model to express the physiological lag parameter. Based on the continuous monitoring of glucose concentration
in interstitial fluid, the project had studied the mass transfer model to establish the evaluation model of the physiological
lag parameter between the glucose concentration in blood and the glucose concentration in interstitial fluid. We have
preliminary achieved to evaluate the physiological lag parameter exactly and predict the glucose concentration in blood
through the glucose concentration in interstitial fluid accurately.
|
