Bimodal BLT source reconstruction based on adjoint diffusion equations

Yanbin Hou; Jimin Liang; Xiaochao Qu; Duofang Chen; Shouping Zhu; Jie Tian

doi:10.1117/12.908126

29 February 2012 Bimodal BLT source reconstruction based on adjoint diffusion equations

Yanbin Hou, Jimin Liang, Xiaochao Qu, Duofang Chen, Shouping Zhu, Jie Tian

Proceedings Volume 8216, Multimodal Biomedical Imaging VII; 82160R (2012) https://doi.org/10.1117/12.908126
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

As one of molecular imaging, bioluminescence tomography (BLT) aims to recover internal source from surface measurement. Being an ill-posed inverse problem, BLT source reconstruction is usually converted to an optimization problem through regularization. In this contribution, we build a bimodal hybrid imaging system consisting of BLT and micro-CT, and then propose an improved source reconstruction method based on adjoint diffusion equations (ADEs). Compared with conventional methods based on constrained minimization problem (CMP), ADEs-based method replaces expensive iterative computation with solving a group of linear ADEs. Given surface flux density, internal source power density and photon fluence rate can be efficiently determined in one step. Both numerical and physical experiments are performed to evaluate the bimodal BLT/micro-CT imaging system and this novel reconstruction method. The relevant results demonstrate the feasibility and potential of this source reconstruction method.

Citation Download Citation

Yanbin Hou, Jimin Liang, Xiaochao Qu, Duofang Chen, Shouping Zhu, and Jie Tian "Bimodal BLT source reconstruction based on adjoint diffusion equations", Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160R (29 February 2012); https://doi.org/10.1117/12.908126

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