Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Jason Zalev; Don Herzog; Bryan Clingman; Tom Miller; Kenneth Kist; N. Carol Dornbluth; B. Michelle McCorvey; Pamela Otto; Sergey Ermilov; Vyacheslav Nadvoretsky; Andre Conjusteau; Richard Su; Dmitri Tsyboulski; Alexander Oraevsky

doi:10.1117/12.910968

23 February 2012 Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors

Jason Zalev, Don Herzog, Bryan Clingman, Tom Miller, Kenneth Kist, N. Carol Dornbluth, B. Michelle McCorvey, Pamela Otto, Sergey Ermilov, Vyacheslav Nadvoretsky, Andre Conjusteau, Richard Su, Dmitri Tsyboulski, Alexander Oraevsky

Author Affiliations +

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82230A (2012) https://doi.org/10.1117/12.910968
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Two-dimensional optoacoustic imaging with a hand-held probe operated in backward mode is being developed for diagnostic imaging of breast cancer to evaluate the feasibility of a dual-modality optoacoustic plus ultrasonic system that maps functional information of anatomical tissue structures with ultrasonic resolution. Tissue is illuminated at 757nm and 1064nm for optical contrast between hypoxic blood of breast carcinomas and normally oxygenated blood in benign masses. The system is optimized and calibrated in phantoms for a pilot clinical study of patients with breast masses suspected for malignancy. Capability of the non-invasive system to improve detection and diagnosis of breast tumors is discussed.

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Jason Zalev, Don Herzog, Bryan Clingman, Tom Miller, Kenneth Kist, N. Carol Dornbluth, B. Michelle McCorvey, Pamela Otto, Sergey Ermilov, Vyacheslav Nadvoretsky, Andre Conjusteau, Richard Su, Dmitri Tsyboulski, and Alexander Oraevsky "Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230A (23 February 2012); https://doi.org/10.1117/12.910968

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