Titanium dioxide-cellulose hybrid nanocomposite based conductometric glucose biosensor

Mohammad Maniruzzaman; Suresha K. Mahadeva; Abu Hasan Khondoker; Jaehwan Kim

doi:10.1117/12.915759

30 March 2012 Titanium dioxide-cellulose hybrid nanocomposite based conductometric glucose biosensor

Mohammad Maniruzzaman, Suresha K. Mahadeva, Abu Hasan Khondoker, Jaehwan Kim

Proceedings Volume 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012; 83440J (2012) https://doi.org/10.1117/12.915759
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2012, San Diego, California, United States

Abstract

This paper investigates the feasibility of conductometric glucose biosensor based on glucose oxidase (GOx) immobilized TiO₂-cellulose hybrid nanocomposite. TiO₂ nanoparticles were blended with cellulose solution prepared by dissolving cotton pulp with lithium chloride/N, N-dimethylacetamide solvent to fabricate TiO₂-cellulose hybrid nanocomposite. The enzyme (GOx) was immobilized into this hybrid material by physical adsorption method. The successful immobilization of GOx into TiO₂-cellulose hybrid nanocomposite via covalent bonding between TiO₂ and GOx was confirmed by X-ray photoelectron analysis. The linear response of our propose glucose biosensor is obtained in the range of 1-10mM with correlation coefficient of 0.93. Our study demonstrates TiO₂-cellulose hybrid material as a potential candidate for an inexpensive, flexible and disposable glucose biosensor.

Citation Download Citation

Mohammad Maniruzzaman, Suresha K. Mahadeva, Abu Hasan Khondoker, and Jaehwan Kim "Titanium dioxide-cellulose hybrid nanocomposite based conductometric glucose biosensor", Proc. SPIE 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012, 83440J (30 March 2012); https://doi.org/10.1117/12.915759

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